Canterbury opened their campaign with a hard-fought win over St George Illawarra and will now have Gold Coast firmly in their sights.
The Bulldogs will welcome Josh Curran back after the forward missed the opener due to suspension, while they will also be able to call upon their captain Stephen Crichton after he avoided a ban for dangerous contact last week.
The last time the Dogs faced the Titans was in Round 3 last year when they toppled the Queensland outfit 32-0 at Belmore.
MORE: Canterbury Bulldogs 2025 NRL draw and schedule
The Bulldogs will host the Titans at Belmore Sports Ground on Sunday, March 16 at 6:15 pm (AEDT).
Stephen Crichton avoided a ban for a dangerous tackle during his side's opening win over the Dragons and will take his place in the centres.
Jacob Kiraz is not expected to return as he continues to recover from his injury.
Sam Hughes dropped out of the starting side and was replaced by Daniel Suluka-Fifita with no time frame provided for Hughes' return yet.
Kurt Mann was named to start at lock but dropped back to the bench in the place of Jaeman Salmon last week. Mann is likely to be named in the No.13 jersey once again.